The worldwide transition to remote and hybrid employment has precipitated sweeping changes in the way organizations approach work tasks and distribute responsibilities, as well as the means in which they evaluate employee performance, especially in those organizations that rely on Business Process Management (BPM) domains. Although BPM focuses on process efficiency, standardization and continuous improvement, implementing it in culturally diverse, distributed teams brings with it some complexities. This paper discusses the impact of cross-cultural variability on workforce optimization in the context of BPM driven work, specifically in the areas of performance management, workflow communications and their delegation through remote and hybrid workforce. The role of a multidisciplinary approach in applying theoretical aspects of BPM as well as cross-cultural management theories and organizational behavior research will serve to inform the development of the integrative framework in the study because it is necessary to enable process optimization to align with cultural adaptability. Based on the recent literature and case studies and the extract of the latest industry practices, the given paper is supposed to provide not only theoretical elements but also practical recommendations on how to manage the globally distributed BPM teams more efficiently.