The Water–Energy–Food (WEF) nexus represents the intricate interdependencies between water resources, energy production, and food security, posing significant challenges for sustainable development. Cross-disciplinary solutions are essential to optimize resource use, minimize environmental impacts, and enhance resilience against climate change. This paper examines integrative strategies that bridge engineering, environmental science, agriculture, and policy-making to address WEF nexus challenges. Key approaches include the implementation of energy-efficient irrigation systems, renewable energy-powered water treatment, and precision agriculture supported by data analytics. Multi-stakeholder collaboration, including governments, industries, and local communities, is emphasized to ensure equitable resource allocation. Furthermore, modeling and decision-support tools facilitate scenario analysis, enabling policymakers to evaluate trade-offs and synergies among water, energy, and food sectors. Case studies from regions experiencing water scarcity and energy stress demonstrate the effectiveness of cross-sectoral strategies, highlighting lessons for broader adoption. The findings underscore the necessity of holistic frameworks that integrate technological innovation, socio-economic considerations, and governance mechanisms to sustainably manage the WEF nexus. By adopting cross-disciplinary approaches, stakeholders can enhance resource efficiency, mitigate conflicts, and promote long-term sustainability.