Digital health passports are emerging as pivotal tools for facilitating safe global mobility, particularly in the context of pandemics and international travel. These digital platforms securely store and verify individuals’ health data, including vaccination status, test results, and medical history, allowing for streamlined travel clearance and risk management. This paper explores the development, deployment, and implications of digital health passports, highlighting technological, regulatory, and ethical considerations. Blockchain, biometrics, and cloud-based systems are increasingly used to ensure data security, authenticity, and interoperability across international borders. The integration of health passports into airline, immigration, and public health infrastructures enables real-time verification and reduces administrative burdens. Key challenges include privacy concerns, data standardization, equitable access, and public acceptance, which necessitate multi-stakeholder collaboration among governments, technology providers, healthcare institutions, and international organizations. Case studies illustrate the effectiveness of pilot programs in enhancing travel safety, minimizing cross-border disease transmission, and restoring traveler confidence. The paper emphasizes that digital health passports not only support public health objectives but also contribute to the resilience and efficiency of global transportation systems. Future research should focus on improving interoperability standards, addressing ethical concerns, and evaluating long-term impacts on mobility, health equity, and international collaboration.